European J Pediatr Surg Rep. 2016; 04(01): 017-021
DOI: 10.1055/s-0036-1582443
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Neonatal Gardner Fibroma Leads to Detection of Familial Adenomatous Polyposis: Two Case Reports

Mattias Schäfer
1   Department of Pediatric Surgery and Urology, Cnopfsche Kinderklinik, Nürnberg, Germany
Martina Kadmon
2   Medicine and Health Sciences, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany
Wolfgang Schmidt
3   Department of Pediatrics, Section Pediatric Oncology, Cnopfsche Kinderklinik, Nürnberg, Germany
Irmgard Treiber
4   Department of General, Visceral, and Transplant Surgery, Universitätsklinikum Heidelberg, Germany
Ute Moog
5   Institute of Human Genetics, Universitätsklinikum Heidelberg, Germany
Christian Sutter
5   Institute of Human Genetics, Universitätsklinikum Heidelberg, Germany
Maximilian Stehr
1   Department of Pediatric Surgery and Urology, Cnopfsche Kinderklinik, Nürnberg, Germany
› Author Affiliations
Further Information

Publication History

20 October 2015

06 March 2016

Publication Date:
13 May 2016 (online)


Gardner fibromas (GFs) have only recently been described as poorly circumscribed tumor-like lesions, which are exceedingly rare in children. GFs are associated with APC gene mutations and therefore with familial adenomatous polyposis (FAP). So far there is only very limited literature on GF in the neonatal period. We present two children with GF diagnosed at birth and subsequent FAP with very different clinical courses. In one case, the disease led to extensive surgery of the thoracic wall and detection of FAP in the father with the need of immediate proctocolectomy. In the other patient (with a positive family history for FAP) the disease remained stable. Our cases indicate that the diagnosis of GF in the neonatal period requires the exclusion of FAP both in the child as well as the parents. Since the clinical behavior of GF cannot be predicted, continuous monitoring is mandatory. Depending on tumor site and growth, individual therapeutic options must be thoroughly considered. Surgical resection, if necessary, has to be inevitably total to prevent recurrence.

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