Thorac cardiovasc Surg
DOI: 10.1055/s-0036-1583525
Review Article
Georg Thieme Verlag KG Stuttgart · New York

The Value of Circulating Biomarkers in Bicuspid Aortic Valve-Associated Aortopathy

Shiho Naito1, Mathias Hillebrand2, Alexander Martin Justus Bernhardt3, Annika Jagodzinski2, Lenard Conradi3, Christian Detter3, Karsten Sydow2, Hermann Reichenspurner3, Yskert von Kodolitsch2, Evaldas Girdauskas3
  • 1Department of Cardiac Surgery, Central Hospital Bad Berka, Bad Berka, Germany
  • 2Department of Cardiology, University Heart Center Hamburg, Hamburg, Germany
  • 3Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
Further Information

Publication History

06 January 2016

14 March 2016

Publication Date:
05 May 2016 (eFirst)


Traditional risk stratification model of bicuspid aortic valve (BAV) aortopathy is based on measurement of maximal cross-sectional aortic diameter, definition of proximal aortic shape, and aortic stiffness/elasticity parameters. However, conventional imaging-based criteria are unable to provide reliable information regarding the risk stratification in BAV aortopathy, especially considering the heterogeneous nature of BAV disease. Given those limitations of conventional imaging, there is a growing clinical interest to use circulating biomarkers in the screening process for thoracic aortic aneurysms as well as in the risk-assessment algorithms. We aimed to systematically review currently available biomarkers, which may be of value to predict the natural evolution of aortopathy in individuals with BAV.