Am J Perinatol 2017; 34(01): 51-61
DOI: 10.1055/s-0036-1584147
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

SENTINEL1: An Observational Study of Respiratory Syncytial Virus Hospitalizations among U.S. Infants Born at 29 to 35 Weeks' Gestational Age Not Receiving Immunoprophylaxis

Evan J. Anderson
1  Departments of Pediatrics and Medicine, Emory University School of Medicine, Atlanta, Georgia
,
Leonard R. Krilov
2  Department of Pediatrics, Winthrop University Hospital, Mineola, New York
,
John P. DeVincenzo
3  Department of Pediatrics, CFRI at Le Bonheur Children's Hospital, University of Tennessee Center for Health Sciences, Memphis, Tennessee
,
Paul A. Checchia
4  Department of Pediatrics, Texas Children's Hospital, Houston, Texas
,
Natasha Halasa
5  Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee
,
Eric A. F. Simões
6  Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado
,
Joseph B. Domachowske
7  Department of Pediatrics, SUNY Upstate Medical University, Syracuse, New York
,
Michael L. Forbes
8  Department of Pediatrics, Akron Children's Hospital, Akron, Ohio
,
Pia S. Pannaraj
9  Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California
,
Scott J. McBride
10  Department of Statistics, United BioSource Corporation, Ann Arbor, Michigan
,
Kimmie K. McLaurin
11  Department of U.S. Medical Affairs, AstraZeneca, Gaithersburg, Maryland
,
Veena R. Kumar
11  Department of U.S. Medical Affairs, AstraZeneca, Gaithersburg, Maryland
,
Christopher S. Ambrose
11  Department of U.S. Medical Affairs, AstraZeneca, Gaithersburg, Maryland
› Author Affiliations
Further Information

Publication History

04 February 2016

21 March 2016

Publication Date:
27 May 2016 (online)

Abstract

Objective SENTINEL1 characterized U.S. preterm infants 29 to 35 weeks' gestational age (wGA) < 12 months old hospitalized for laboratory-confirmed respiratory syncytial virus (RSV) disease and not receiving RSV immunoprophylaxis during the 2014 to 2015 RSV season.

Study Design This is a noninterventional, observational, cohort study.

Results A total of 702 infants were hospitalized with community-acquired RSV disease, of whom an estimated 42% were admitted to the intensive care unit (ICU) and 20% required invasive mechanical ventilation (IMV). Earlier gestational age and younger chronologic age were associated with an increased frequency of RSV-confirmed hospitalization (RSVH), ICU admission, and IMV. Among infants 29 to 32 wGA and < 3 months of age, 68% required ICU admission and 44% required IMV. One death occurred of an infant 29 wGA. Among the 212 infants enrolled for in-depth analysis of health care resource utilization, mean and median RSVH charges were $55,551 and $27,461, respectively, which varied by intensity of care required. Outpatient visits were common, with 63% and 62% of infants requiring visits before and within 1 month following the RSVH, respectively.

Conclusion Preterm infants 29 to 35 wGA are at high risk for severe RSV disease, which imposes a substantial health burden, particularly in the first months of life.

Supplementary Material