Am J Perinatol 2017; 34(01): 51-61
DOI: 10.1055/s-0036-1584147
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

SENTINEL1: An Observational Study of Respiratory Syncytial Virus Hospitalizations among U.S. Infants Born at 29 to 35 Weeks' Gestational Age Not Receiving Immunoprophylaxis

Evan J. Anderson
1  Departments of Pediatrics and Medicine, Emory University School of Medicine, Atlanta, Georgia
Leonard R. Krilov
2  Department of Pediatrics, Winthrop University Hospital, Mineola, New York
John P. DeVincenzo
3  Department of Pediatrics, CFRI at Le Bonheur Children's Hospital, University of Tennessee Center for Health Sciences, Memphis, Tennessee
Paul A. Checchia
4  Department of Pediatrics, Texas Children's Hospital, Houston, Texas
Natasha Halasa
5  Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee
Eric A. F. Simões
6  Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado
Joseph B. Domachowske
7  Department of Pediatrics, SUNY Upstate Medical University, Syracuse, New York
Michael L. Forbes
8  Department of Pediatrics, Akron Children's Hospital, Akron, Ohio
Pia S. Pannaraj
9  Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California
Scott J. McBride
10  Department of Statistics, United BioSource Corporation, Ann Arbor, Michigan
Kimmie K. McLaurin
11  Department of U.S. Medical Affairs, AstraZeneca, Gaithersburg, Maryland
Veena R. Kumar
11  Department of U.S. Medical Affairs, AstraZeneca, Gaithersburg, Maryland
Christopher S. Ambrose
11  Department of U.S. Medical Affairs, AstraZeneca, Gaithersburg, Maryland
› Author Affiliations
Further Information

Publication History

04 February 2016

21 March 2016

Publication Date:
27 May 2016 (online)


Objective SENTINEL1 characterized U.S. preterm infants 29 to 35 weeks' gestational age (wGA) < 12 months old hospitalized for laboratory-confirmed respiratory syncytial virus (RSV) disease and not receiving RSV immunoprophylaxis during the 2014 to 2015 RSV season.

Study Design This is a noninterventional, observational, cohort study.

Results A total of 702 infants were hospitalized with community-acquired RSV disease, of whom an estimated 42% were admitted to the intensive care unit (ICU) and 20% required invasive mechanical ventilation (IMV). Earlier gestational age and younger chronologic age were associated with an increased frequency of RSV-confirmed hospitalization (RSVH), ICU admission, and IMV. Among infants 29 to 32 wGA and < 3 months of age, 68% required ICU admission and 44% required IMV. One death occurred of an infant 29 wGA. Among the 212 infants enrolled for in-depth analysis of health care resource utilization, mean and median RSVH charges were $55,551 and $27,461, respectively, which varied by intensity of care required. Outpatient visits were common, with 63% and 62% of infants requiring visits before and within 1 month following the RSVH, respectively.

Conclusion Preterm infants 29 to 35 wGA are at high risk for severe RSV disease, which imposes a substantial health burden, particularly in the first months of life.

Supplementary Material