Thorac Cardiovasc Surg 2017; 65(03): 174-181
DOI: 10.1055/s-0036-1584571
Original Cardiovascular
Georg Thieme Verlag KG Stuttgart · New York

Preoperative Predictors and Outcome of Triple Valve Surgery in 487 Consecutive Patients

Thilo Noack
1   Department of Cardiac Surgery, Heart Center Leipzig University, Leipzig, Germany
,
Fabian Emrich
1   Department of Cardiac Surgery, Heart Center Leipzig University, Leipzig, Germany
,
Philipp Kiefer
1   Department of Cardiac Surgery, Heart Center Leipzig University, Leipzig, Germany
,
Alexandro Hoyer
1   Department of Cardiac Surgery, Heart Center Leipzig University, Leipzig, Germany
,
David Michael Holzhey
1   Department of Cardiac Surgery, Heart Center Leipzig University, Leipzig, Germany
,
Piroze Davierwala
1   Department of Cardiac Surgery, Heart Center Leipzig University, Leipzig, Germany
,
Martin Misfeld
1   Department of Cardiac Surgery, Heart Center Leipzig University, Leipzig, Germany
,
Farhad Bakhtiary
1   Department of Cardiac Surgery, Heart Center Leipzig University, Leipzig, Germany
,
Joerg Seeburger
1   Department of Cardiac Surgery, Heart Center Leipzig University, Leipzig, Germany
,
Friedrich-Wilhelm Mohr
1   Department of Cardiac Surgery, Heart Center Leipzig University, Leipzig, Germany
› Institutsangaben
Weitere Informationen

Publikationsverlauf

16. November 2015

13. Mai 2016

Publikationsdatum:
07. Juli 2016 (online)

Abstract

Background Triple valve surgery (TVS) is associated with an elevated risk for operative mortality and thus remains a surgical challenge. We report our experience and results of TVS procedures, especially with respect to identification of preoperative risk factors, to improve patient selection.

Methods Between December 1994 and January 2013, 487 consecutive patients (240 male, 247 female) underwent TVS at the Heart Center Leipzig, University of Leipzig. The data were prospectively collected and retrospectively analyzed. Univariate and multivariable regression analyses were performed to identify risk factors.

Results The 30-day mortality was 16.1% and the long-term survival at 1 year and 5 years was 71.8% and 54.6%, respectively. Multivariable logistic regression analysis identified previous myocardial infarction to be the only significant predictor for early mortality. Age, New York Heart Association functional class IV, previous myocardial infarction, dialysis, and liver dysfunction were identified as preoperative predictors for late mortality. Furthermore, an increase of operative risk, given for each year, was observed during the study period. In contrast, 30-day mortality decreased during the observation time.

Conclusion TVS is associated with a high surgical risk. Long-term survival is decreased, but acceptable for these high-risk patients. The series demonstrates that increasing surgical risk, age, and comorbidities are the future challenges in TVS.

 
  • References

  • 1 Pagni S, Ganzel BL, Singh R , et al. Clinical outcome after triple-valve operations in the modern era: are elderly patients at increased surgical risk?. Ann Thorac Surg 2014; 97 (2) 569-576
  • 2 Gravel GM, Bouchard D, Perrault LP , et al. Triple-valve surgery: clinical results of a three-decade experience. J Heart Valve Dis 2011; 20 (1) 75-82
  • 3 Alsoufi B, Rao V, Borger MA , et al. Short- and long-term results of triple valve surgery in the modern era. Ann Thorac Surg 2006; 81 (6) 2172-2177 , discussion 2177–2178
  • 4 Gersh BJ, Schaff HV, Vatterott PJ , et al. Results of triple valve replacement in 91 patients: perioperative mortality and long-term follow-up. Circulation 1985; 72 (1) 130-137
  • 5 Galloway AC, Grossi EA, Baumann FG , et al. Multiple valve operation for advanced valvular heart disease: results and risk factors in 513 patients. J Am Coll Cardiol 1992; 19 (4) 725-732
  • 6 Han QQ, Xu ZY, Zhang BR, Zou LJ, Hao JH, Huang SD. Primary triple valve surgery for advanced rheumatic heart disease in Mainland China: a single-center experience with 871 clinical cases. Eur J Cardiothorac Surg 2007; 31 (5) 845-850
  • 7 Akay TH, Gultekin B, Ozkan S , et al. Triple-valve procedures: impact of risk factors on midterm in a rheumatic population. Ann Thorac Surg 2006; 82 (5) 1729-1734
  • 8 Davoodi S, Karimi A, Ahmadi SH , et al. Short- and mid-term results of triple-valve surgery with an evaluation of postoperative quality of life. Tex Heart Inst J 2009; 36 (2) 125-130
  • 9 Lio A, Murzi M, Di Stefano G , et al. Triple valve surgery in the modern era: short- and long-term results from a single centre. Interact Cardiovasc Thorac Surg 2014; 19 (6) 978-984
  • 10 Peterss S, Fortmann C, Pichlmaier M , et al. Advanced age: a contraindication for triple-valve surgery?. J Heart Valve Dis 2012; 21 (5) 641-649
  • 11 Shinn SH, Oh SS, Na CY , et al. Short- and long-term results of triple valve surgery: a single center experience. J Korean Med Sci 2009; 24 (5) 818-823
  • 12 Akins CW, Miller DC, Turina MI , et al; Councils of the American Association for Thoracic Surgery; Society of Thoracic Surgeons; European Assoication for Cardio-Thoracic Surgery; Ad Hoc Liaison Committee for Standardizing Definitions of Prosthetic Heart Valve Morbidity. Guidelines for reporting mortality and morbidity after cardiac valve interventions. J Thorac Cardiovasc Surg 2008; 135 (4) 732-738
  • 13 Hermans H, Tjahjono M, Faes D , et al. Mid-term follow up of triple valve surgery in a western community: predictors of survival. J Heart Valve Dis 2010; 19 (5) 644-651 , discussion 652
  • 14 Fadel BM, Alsoufi B, Manlhiot C , et al. Determinants of short- and long-term outcomes following triple valve surgery. J Heart Valve Dis 2010; 19 (4) 513-522 , discussion 523
  • 15 Beckmann A, Funkat AK, Lewandowski J , et al. Cardiac surgery in Germany during 2014: A report on behalf of the German Society for Thoracic and Cardiovascular Surgery. Thorac Cardiovasc Surg 2015; 63 (4) 258-269
  • 16 Lee R, Li S, Rankin JS , et al; Society of Thoracic Surgeons Adult Cardiac Surgical Database. Fifteen-year outcome trends for valve surgery in North America. Ann Thorac Surg 2011; 91 (3) 677-684 , discussion 684
  • 17 Maganti M, Badiwala M, Sheikh A , et al. Predictors of low cardiac output syndrome after isolated mitral valve surgery. J Thorac Cardiovasc Surg 2010; 140 (4) 790-796
  • 18 Maganti MD, Rao V, Borger MA, Ivanov J, David TE. Predictors of low cardiac output syndrome after isolated aortic valve surgery. Circulation 2005; 112 9, Suppl): I448-I452
  • 19 Prendergast BD, Tornos P. Surgery for infective endocarditis: who and when?. Circulation 2010; 121 (9) 1141-1152
  • 20 Peduzzi P, Concato J, Feinstein AR, Holford TR. Importance of events per independent variable in proportional hazards regression analysis. II. Accuracy and precision of regression estimates. J Clin Epidemiol 1995; 48 (12) 1503-1510
  • 21 Zwiener I, Blettner M, Hommel G. Survival analysis: part 15 of a series on evaluation of scientific publications. Dtsch Arztebl Int 2011; 108 (10) 163-169
  • 22 Sterbetafeln und Lebenserwartung. https://www.destatis.de/DE/ZahlenFakten/GesellschaftStaat/Bevoelkerung/Sterbefaelle/AktuellPeriodensterbetafeln.html . Accessed April 02, 2016