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Journal of Pediatric Epilepsy 2017; 06(01): 037-043
DOI: 10.1055/s-0036-1584932
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Serial Neuropsychological Evaluation of Children with Severe Epilepsy

William S. MacAllister
1   Department of Neurology, Comprehensive Epilepsy Center, New York University, New York, United States
,
Hilary Murphy
1   Department of Neurology, Comprehensive Epilepsy Center, New York University, New York, United States
2   Icahn School of Medicine at Mount Sinai, New York, United States
,
Kelly Coulehan
3   Department of Psychology, Fordham University, New York, United States
› Author Affiliations
Further Information

Publication History

02 March 2015

21 March 2016

Publication Date:
21 July 2016 (online)

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Abstract

Cognitive impairment is common in children and adolescents with epilepsy. Though there is increasing recognition that even children with more benign epilepsy syndromes may show cognitive loss over time, this is particularly true in children with severe epilepsies, termed the epileptic encephalopathies. The current article discusses general cognition in children with epilepsy, focusing on risk factors for cognitive decline over time in severe epilepsies. The “epileptic encephalopathies” are briefly introduced and methods for assessing cognitive loss over time are discussed with an emphasis on the use of reliable change indices. The strengths and the limitations of this approach are noted as they pertain to children. The article concludes with an illustrative case example of a young child with a severe epilepsy syndrome and apparent cognitive loss. The utility and limitations of reliable change indices are discussed within the context of this case.

Keywords

epilepsy - children - epileptic encephalopathies - reliable change index
 

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