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Semin Neurol 2016; 36(04): 330-334
DOI: 10.1055/s-0036-1585097
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Parkinsonism

Adrienne M. Keener
1   Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California
,
Yvette M. Bordelon
1   Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California
› Author Affiliations
Further Information

Publication History

Publication Date:
19 September 2016 (online)

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Abstract

Parkinsonism is a clinical syndrome, which is characterized by bradykinesia, rigidity, rest tremor, and postural instability. Idiopathic Parkinson disease (PD) is the most common cause of this syndrome, though there are several other important etiologies that must be considered. These include the atypical Parkinsonian disorders multiple system atrophy (MSA), dementia with Lewy Bodies (DLB), progressive supranuclear palsy (PSP), and corticobasal syndrome (CBS); as well as secondary causes of parkinsonism. These various disease entities may be distinguished based on key clinical features, which is critical for the purposes of diagnosis, treatment, and prognosis.

Keywords

Parkinsonism - Parkinson disease - atypical Parkinsonian disorders - Parkinson plus disorders - secondary Parkinsonism
 

  • References

  • 1 Roze E, Coêlho-Braga MC, Gayraud D , et al. Head tremor in Parkinson's disease. Mov Disord 2006; 21 (8) 1245-1248
    CrossrefPubMedGoogle Scholar
  • 2 Ashour R, Tintner R, Jankovic J. Striatal deformities of the hand and foot in Parkinson's disease. Lancet Neurol 2005; 4 (7) 423-431
    CrossrefPubMedGoogle Scholar
  • 3 Zetusky WJ, Jankovic J, Pirozzolo FJ. The heterogeneity of Parkinson's disease: clinical and prognostic implications. Neurology 1985; 35 (4) 522-526
    CrossrefPubMedGoogle Scholar
  • 4 Jankovic J, Beach J, Schwartz K, Contant C. Tremor and longevity in relatives of patients with Parkinson's disease, essential tremor, and control subjects. Neurology 1995; 45 (4) 645-648
    CrossrefPubMedGoogle Scholar
  • 5 Post B, Merkus MP, de Haan RJ, Speelman JD ; CARPA Study Group. Prognostic factors for the progression of Parkinson's disease: a systematic review. Mov Disord 2007; 22 (13) 1839-1851 , quiz 1988
    CrossrefPubMedGoogle Scholar
  • 6 Fereshtehnejad SM, Romenets SR, Anang JB, Latreille V, Gagnon JF, Postuma RB. New clinical subtypes of Parkinson disease and their longitudinal progression: a prospective cohort comparison with other phenotypes. JAMA Neurol 2015; 72 (8) 863-873
    CrossrefPubMedGoogle Scholar
  • 7 Jankovic J, Schwartz KS, Ondo W. Re-emergent tremor of Parkinson's disease. J Neurol Neurosurg Psychiatry 1999; 67 (5) 646-650
    CrossrefPubMedGoogle Scholar
  • 8 Koller WC. Sensory symptoms in Parkinson's disease. Neurology 1984; 34 (7) 957-959
    CrossrefPubMedGoogle Scholar
  • 9 Riley D, Lang AE, Blair RD, Birnbaum A, Reid B. Frozen shoulder and other shoulder disturbances in Parkinson's disease. J Neurol Neurosurg Psychiatry 1989; 52 (1) 63-66
    CrossrefPubMedGoogle Scholar
  • 10 Stamey W, Davidson A, Jankovic J. Shoulder pain: a presenting symptom of Parkinson disease. J Clin Rheumatol 2008; 14 (4) 253-254
    CrossrefPubMedGoogle Scholar
  • 11 Boeve BF, Silber MH, Ferman TJ, Lucas JA, Parisi JE. Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy. Mov Disord 2001; 16 (4) 622-630
    CrossrefPubMedGoogle Scholar
  • 12 Howell MJ, Schenck CH. Rapid eye movement sleep behavior disorder and neurodegenerative disease. JAMA Neurol 2015; 72 (6) 707-712
    CrossrefPubMedGoogle Scholar
  • 13 Postuma RB, Aarsland D, Barone P , et al. Identifying prodromal Parkinson's disease: pre-motor disorders in Parkinson's disease. Mov Disord 2012; 27 (5) 617-626
    CrossrefPubMedGoogle Scholar
  • 14 Simuni T, Sethi K. Nonmotor manifestations of Parkinson's disease. Ann Neurol 2008; 64 (Suppl. 02) S65-S80
    CrossrefPubMedGoogle Scholar
  • 15 Gilman S, Wenning GK, Low PA , et al. Second consensus statement on the diagnosis of multiple system atrophy. Neurology 2008; 71 (9) 670-676
    CrossrefPubMedGoogle Scholar
  • 16 Wenning GK, Geser F, Krismer F , et al; European Multiple System Atrophy Study Group. The natural history of multiple system atrophy: a prospective European cohort study. Lancet Neurol 2013; 12 (3) 264-274
    CrossrefPubMedGoogle Scholar
  • 17 Merlo IM, Occhini A, Pacchetti C, Alfonsi E. Not paralysis, but dystonia causes stridor in multiple system atrophy. Neurology 2002; 58 (4) 649-652
    CrossrefPubMedGoogle Scholar
  • 18 Jecmenica-Lukic M, Poewe W, Tolosa E, Wenning GK. Premotor signs and symptoms of multiple system atrophy. Lancet Neurol 2012; 11 (4) 361-368
    CrossrefPubMedGoogle Scholar
  • 19 Klein C, Brown R, Wenning G, Quinn N. The “cold hands sign” in multiple system atrophy. Mov Disord 1997; 12 (4) 514-518
    CrossrefPubMedGoogle Scholar
  • 20 Massey LA, Micallef C, Paviour DC , et al. Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophy. Mov Disord 2012; 27 (14) 1754-1762
    CrossrefPubMedGoogle Scholar
  • 21 Brooks DJ, Seppi K ; Neuroimaging Working Group on MSA. Proposed neuroimaging criteria for the diagnosis of multiple system atrophy. Mov Disord 2009; 24 (7) 949-964
    CrossrefPubMedGoogle Scholar
  • 22 Heidebrink JL. Is dementia with Lewy bodies the second most common cause of dementia?. J Geriatr Psychiatry Neurol 2002; 15 (4) 182-187
    CrossrefPubMedGoogle Scholar
  • 23 McKeith IG, Dickson DW, Lowe J , et al; Consortium on DLB. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 2005; 65 (12) 1863-1872
    CrossrefPubMedGoogle Scholar
  • 24 Collerton D, Burn D, McKeith I, O'Brien J. Systematic review and meta-analysis show that dementia with Lewy bodies is a visual-perceptual and attentional-executive dementia. Dement Geriatr Cogn Disord 2003; 16 (4) 229-237
    CrossrefPubMedGoogle Scholar
  • 25 Steele JC, Richardson JC, Olszewski J. Progressive supranuclear palsy: a heterogeneous degeneration involving the brain stem, basal ganglia and cerebellum, with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. Arch Neurol 1964; 10: 333-359
    CrossrefPubMedGoogle Scholar
  • 26 Litvan I, Agid Y, Calne D , et al. Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology 1996; 47 (1) 1-9
    CrossrefPubMedGoogle Scholar
  • 27 Golbe LI. Progressive supranuclear palsy. Semin Neurol 2014; 34 (2) 151-159
    Article in Thieme ConnectPubMedGoogle Scholar
  • 28 Armstrong MJ, Litvan I, Lang AE , et al. Criteria for the diagnosis of corticobasal degeneration. Neurology 2013; 80 (5) 496-503
    CrossrefPubMedGoogle Scholar
  • 29 Stamelou M, Alonso-Canovas A, Bhatia KP. Dystonia in corticobasal degeneration: a review of the literature on 404 pathologically proven cases. Mov Disord 2012; 27 (6) 696-702
    CrossrefPubMedGoogle Scholar
  • 30 Whitwell JL, Jack Jr CR, Boeve BF , et al. Imaging correlates of pathology in corticobasal syndrome. Neurology 2010; 75 (21) 1879-1887
    CrossrefPubMedGoogle Scholar
  • 31 Curran T, Lang AE. Parkinsonian syndromes associated with hydrocephalus: case reports, a review of the literature, and pathophysiological hypotheses. Mov Disord 1994; 9 (5) 508-520
    CrossrefPubMedGoogle Scholar
  • 32 Akiguchi I, Ishii M, Watanabe Y , et al. Shunt-responsive parkinsonism and reversible white matter lesions in patients with idiopathic NPH. J Neurol 2008; 255 (9) 1392-1399
    CrossrefPubMedGoogle Scholar
  • 33 Korczyn AD. Vascular parkinsonism—characteristics, pathogenesis and treatment. Nat Rev Neurol 2015; 11 (6) 319-326
    CrossrefPubMedGoogle Scholar
  • 34 Vizcarra JA, Lang AE, Sethi KD, Espay AJ. Vascular parkinsonism: deconstructing a syndrome. Mov Disord 2015; 30 (7) 886-894
    CrossrefPubMedGoogle Scholar
  • 35 Susatia F, Fernandez HH. Drug-induced parkinsonism. Curr Treat Options Neurol 2009; 11 (3) 162-169
    CrossrefPubMedGoogle Scholar
  • 36 Kim JS, Youn J, Shin H, Cho JW. Nonmotor symptoms in drug-induced parkinsonism and drug-naïve Parkinson disease. Can J Neurol Sci 2013; 40 (1) 36-41
    CrossrefPubMedGoogle Scholar