What Is the Best Initial Empirical Treatment of Suspected Sepsis in a Newborn Readmitted Soon after Discharge Home in an Era of Increased Resistance to Antibiotics? A Report of Two Cases

Elio Castagnola; Livia Gargiullo; Salvatore Renna; Anna Loy; Francesco Risso; Andrea Moscatelli; Ivana Baldelli; Giuliana Cangemi; Roberto Bandettini

doi:10.1055/s-0036-1586104

American Journal of Perinatology, Table of Contents

Am J Perinatol 2016; 33(11): 1090-1092
DOI: 10.1055/s-0036-1586104

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

What Is the Best Initial Empirical Treatment of Suspected Sepsis in a Newborn Readmitted Soon after Discharge Home in an Era of Increased Resistance to Antibiotics? A Report of Two Cases

Authors

Elio Castagnola

¹Istituto Giannina Gaslini Children's Hospital, Genoa, Italy
Livia Gargiullo

²Ospedale Pediatrico Bambino Gesù, Rome, Italy
Salvatore Renna

¹Istituto Giannina Gaslini Children's Hospital, Genoa, Italy
Anna Loy

¹Istituto Giannina Gaslini Children's Hospital, Genoa, Italy
Francesco Risso

¹Istituto Giannina Gaslini Children's Hospital, Genoa, Italy
Andrea Moscatelli

¹Istituto Giannina Gaslini Children's Hospital, Genoa, Italy
Ivana Baldelli

¹Istituto Giannina Gaslini Children's Hospital, Genoa, Italy
Giuliana Cangemi

¹Istituto Giannina Gaslini Children's Hospital, Genoa, Italy
Roberto Bandettini

¹Istituto Giannina Gaslini Children's Hospital, Genoa, Italy

Abstract

Background Colonization/infection by antibiotic-resistant bacteria is becoming a major threat to health care systems.

Case report Two septic neonates were readmitted in our hospital few days after hospital discharge. In both of them, microbiological workup revealed an infection caused by multiresistant pathogens. Noteworthy, one baby had received intensive care management for 4 weeks, whereas the other had been vaginally delivered and sent home on his second day of life.

Conclusion These cases suggest that in countries and/or hospital with high prevalence of colonization/infection by resistant pathogens in nurseries, neonatal intensive care units, and obstetric wards, the choice of initial therapy of suspected sepsis in a neonate readmitted from home soon after discharge should take into account the possibility of an infection due to a multiresistant pathogen.

Keywords

antibiotic-resistant pathogen - neonate - suspected sepsis - initial empirical treatment

Full Text

References

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