Abstract
Gestational diabetes mellitus (GDM) is linked with several acute maternal health risks
and long-term development of type 2 diabetes, metabolic syndrome, and cardiovascular
disease. Intrauterine exposure to GDM similarly increases offspring risk of early-life
health complications and later disease. GDM recurrence is common, affecting 40 to
73% of women, and augments associated maternal/fetal/child health risks. Modifiable
and independent risk factors for GDM include maternal excessive gestational weight
gain and prepregnancy overweight and obesity. Lifestyle interventions that target
diet, activity, and behavioral strategies can effectively modify body weight. Randomized
clinical trials testing the effects of lifestyle interventions during pregnancy to
reduce excessive gestational weight gain have generally shown mixed effects on reducing
GDM incidence. Trials testing the effects of postpartum lifestyle interventions among
women with a history of GDM have shown reduced incidence of diabetes and improved
cardiovascular disease risk factors. However, the long-term effects of interpregnancy
or prepregnancy lifestyle interventions on subsequent GDM remain unknown. Future adequately
powered and well-controlled clinical trials are needed to determine the effects of
lifestyle interventions to prevent GDM and identify pathways to effectively reach
reproductive-aged women across all levels of society, before, during, and after pregnancy.
Keywords
lifestyle intervention - gestational diabetes mellitus - postpartum - preconception
- inter-pregnancy