Asymmetric Allylation of 2-Oxocycloalkanecarboxylates

Abstract

In this study, the highly enantioselective α-allylation of α-substituted β-ketoesters, particularly 2-oxocycloalkanecarboxylates, is achieved by synergistic catalysis with an achiral palladium complex and a chiral primary amino acid. Various α-allylated β-ketoesters containing a quaternary carbon stereogenic center are synthesized in high yields (up to 97%) with excellent enantioselectivity (up to 99% ee).

Key words

allylation - amino acids - asymmetric catalysis - ketones - palladium

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