CC BY ND NC 4.0 · SynOpen 2017; 01(01): 0008-0010
DOI: 10.1055/s-0036-1588167
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Ultrasound-Accelerated Amide Coupling Reactions Directed toward the Synthesis of 1-Acetyl-3-carboxamide-β-carboline Derivatives of Biological Importance

N. Sharmaa, P. Kumaria, P. Sharmaa, N. Bhagatb, S. Bhagat*a
  • aOrganic Synthesis research Laboratory, Department of Chemistry, A.R.S.D. College, University of Delhi, New Delhi-110021, India
  • bInstrumentation & Control Engineering, Netaji Subash Institute of Technology, University of Delhi, Azad Hind Fauz Marg, Dwarka, Delhi-110078, India   Email: sunitabhagat28@gmail.com
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Publication History

Received: 03 February 2017

Accepted after revision: 12 March 2017

Publication Date:
22 March 2017 (online)

Abstract

Several biologically important 1-acetyl-3-carboxamide-β-carboline derivatives were rapidly synthesized by ultrasound-promoted amide coupling of 1-acetyl-9H-pyrido[3,4-b]indole-3-carboxylic acid with substituted aromatic amines. The major advantages of the proposed method are that use of ultrasound irradiations afforded the desired products in a drastically reduced reaction time and in excellent yields compared with conventional stirring.

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