Synlett 2017; 28(05): 509-514
DOI: 10.1055/s-0036-1588392
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© Georg Thieme Verlag Stuttgart · New York

Recent Progress of Transition-Metal-Catalyzed Enantioselective Hydroalkynylation of Alkenes

Zi-Xuan Wang
Center of Basic Molecular Science, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. of China   Email: bijieli@mail.tsinghua.edu.cn
,
Xiao-Yan Bai
Center of Basic Molecular Science, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. of China   Email: bijieli@mail.tsinghua.edu.cn
,
Bi-Jie Li*
Center of Basic Molecular Science, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. of China   Email: bijieli@mail.tsinghua.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 24 November 2016

Accepted: 12 December 2016

Publication Date:
11 January 2017 (online)

Abstract

Catalytic asymmetric hydroalkynylation of unsaturated alkenes provides a straightforward method to construct stereocenters substituted by an alkynyl group. Here we provide an overview of the recent progress of catalytic asymmetric hydroalkynylation reactions. Our recent development of an iridium-catalyzed enantioselective hydroalkynylation of enamides is also discussed.

1 Introduction

2 Catalytic Asymmetric Hydroalkynylation of Electron-Deficient Alkenes

3 Catalytic Asymmetric Hydroalkynylation of Electron-Neutral Alkenes

4 Catalytic Asymmetric Hydroalkynylation of Electron-Rich Alkenes

5 Conclusion

 
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