Synthesis 2017; 49(23): 5251-5257
DOI: 10.1055/s-0036-1588486
paper
© Georg Thieme Verlag Stuttgart · New York

Domino Reactions of 1-Aroyl-3,4-dihydroisoquinolines with α,β-Unsaturated Aldehydes

Maria D. Matveeva
Peoples’ Friendship University of Russia (RUDN University), 6, Mikluho-Maklaya St., Moscow 117198, Russian Federation   Email: lvoskressensky@sci.pfu.edu.ru
,
Tatiana N. Borisova
Peoples’ Friendship University of Russia (RUDN University), 6, Mikluho-Maklaya St., Moscow 117198, Russian Federation   Email: lvoskressensky@sci.pfu.edu.ru
,
Alexander A. Titov
Peoples’ Friendship University of Russia (RUDN University), 6, Mikluho-Maklaya St., Moscow 117198, Russian Federation   Email: lvoskressensky@sci.pfu.edu.ru
,
Lada V. Anikina
Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Russian Federation
,
Svetlana V. Dyachenko
Peoples’ Friendship University of Russia (RUDN University), 6, Mikluho-Maklaya St., Moscow 117198, Russian Federation   Email: lvoskressensky@sci.pfu.edu.ru
,
Grigorii S. Astakhov
Peoples’ Friendship University of Russia (RUDN University), 6, Mikluho-Maklaya St., Moscow 117198, Russian Federation   Email: lvoskressensky@sci.pfu.edu.ru
,
Alexey V. Varlamov
Peoples’ Friendship University of Russia (RUDN University), 6, Mikluho-Maklaya St., Moscow 117198, Russian Federation   Email: lvoskressensky@sci.pfu.edu.ru
,
Leonid G. Voskressensky*
Peoples’ Friendship University of Russia (RUDN University), 6, Mikluho-Maklaya St., Moscow 117198, Russian Federation   Email: lvoskressensky@sci.pfu.edu.ru
› Author Affiliations
This work was supported by the Russian Foundation for Basic Research (grant 17-03-00605) and was financially supported by the Ministry of Education and Science of the Russian Federation (agreement no. 02.a03.21.0008).
Further Information

Publication History

Received: 16 April 2017

Accepted after revision: 12 June 2017

Publication Date:
22 August 2017 (eFirst)

Abstract

An efficient synthesis of pyrrolo[2,1-a]isoquinolines by a domino reaction from a variety of 3,4-dihydropyrrolo[2,1-a]isoquinolines and α,β-unsaturated aldehydes in the absence of catalyst in good yields under microwave irradiation, is reported.

Supporting Information

 
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