DOI: 10.1055/s-0036-1588488
© Georg Thieme Verlag Stuttgart · New York

(HMe2SiCH2)2: A Useful Reagent for B(C6F5)3-Catalyzed Reduction–Lactonization of Keto Acids: Concise Syntheses of (–)-cis-Whisky and (–)-cis-Cognac Lactones

Hengmu Xiea, Ji Lua, Yingying Guia, Lu Gaoa, Zhenlei Song*a, b
  • aKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, 610041,, P. R. of China   Email:
  • bState Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin, 300071, P. R. of China
We are grateful for financial support from the National Natural Science Foundation of China (21290180, 21622202, 21502125).
Further Information

Publication History

Received: 23 April 2017

Accepted after revision: 10 June 2017

Publication Date:
19 July 2017 (eFirst)

Published as part of the Cluster Silicon in Synthesis and Catalysis


(HMe2SiCH2)2 has been utilized as a useful reagent for B(C6F5)3-catalyzed reduction–lactonization of keto acids to synthesize γ- and δ-lactones. The process led concisely to (–)-cis-whisky and (–)-cis-cognac lactones in respective overall yields of 32% and 36%.

Supporting Information