(HMe2SiCH2)2: A Useful Reagent for B(C6F5)3-Catalyzed Reduction–Lactonization of Keto Acids: Concise Syntheses of (–)-cis-Whisky and (–)-cis-Cognac LactonesWe are grateful for financial support from the National Natural Science Foundation of China (21290180, 21622202, 21502125).
Received: 23 April 2017
Accepted after revision: 10 June 2017
19 July 2017 (eFirst)
Published as part of the Cluster Silicon in Synthesis and Catalysis
(HMe2SiCH2)2 has been utilized as a useful reagent for B(C6F5)3-catalyzed reduction–lactonization of keto acids to synthesize γ- and δ-lactones. The process led concisely to (–)-cis-whisky and (–)-cis-cognac lactones in respective overall yields of 32% and 36%.