Concise Synthesis of a Cyclopentane Intermediate Possessing All Nitrogen Functionalities for PactamycinThis work was supported by a Grant-in-Aid for Scientific Research (B) (No. 16H04915) and a Grant-in-Aid for Scientific Research on Innovative Areas ‘Chemical Biology of Natural Products’ (No. 23102015) from MEXT. N.M. thanks the Global COE program and the Program for Leading Graduate Schools: IGER Program in Green Natural Sciences from MEXT.
Received: 23 May 2017
Accepted after revision: 20 June 2017
27 July 2017 (eFirst)
Dedicated to Prof. Dr. Volker Jäger
Pactamycin, a potent antitumor and antimicrobial antibiotic, possesses a densely functionalized cyclopentane core structure. This paper describes the concise synthesis of an advanced intermediate for synthesizing the enantiomer of pactamycin that contains the cyclopentane skeleton bearing all the necessary amino functions with correct stereochemistries.