Aqueous-Medium Selective Modification of Cysteine and Related Thiols with Tricyclic Oxygen-HeterocyclesThis work was partially supported by JSPS KAKENHI Grant-in-Aid for Scientific Research (C) Grant Number 15K07879 (to E.Y.).
Received: 17 May 2017
Accepted after revision: 19 June 2017
25 July 2017 (eFirst)
The utility of tricyclic oxygen-heterocycles as a reagent for the thiol-selective modification toward bioconjugation was demonstrated by the use of l-cysteine, homocysteine, captopril, and glutathione as a nucleophile having a thiol group. These trapping reactions proceeded under the mild and aqueous reaction conditions.