DOI: 10.1055/s-0036-1588513
© Georg Thieme Verlag Stuttgart · New York

Palladium-Catalyzed Copper-Free Sonogashira Coupling of 2-Bromoarylcarbonyls: Synthesis of Isobenzofurans via One-Pot Reductive Cyclization

Alavala Gopi Krishna Reddy, Gedu Satyanarayana*
  • Department of Chemistry, Indian Institute of Technology, Hyderabad, Kandi – 502 285, Sangareddy, Telangana, India   Email:
We are grateful to the Council of Scientific and Industrial Research (CSIR), New Delhi, for the financial support [Sanction No. 02(0262)/16/EMR-11].
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Publication History

Received: 27 June 2017

Accepted after revision: 29 June 2017

Publication Date:
02 August 2017 (eFirst)


Palladium-catalyzed copper-free Sonogashira coupling of 2-bromocarbonyls is presented. This method afforded the 2-alkynylaryl carbonyls, useful synthons for the accomplishment of many carbocyclic and heterocyclic motifs. Significantly, the strategy was extended to the one-pot synthesis of isobenzofurans via reduction followed by intramolecular 5-exo-dig cyclization.

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