Palladium-Catalyzed Copper-Free Sonogashira Coupling of 2-Bromoarylcarbonyls: Synthesis of Isobenzofurans via One-Pot Reductive CyclizationWe are grateful to the Council of Scientific and Industrial Research (CSIR), New Delhi, for the financial support [Sanction No. 02(0262)/16/EMR-11].
Received: 27 June 2017
Accepted after revision: 29 June 2017
02 August 2017 (eFirst)
Palladium-catalyzed copper-free Sonogashira coupling of 2-bromocarbonyls is presented. This method afforded the 2-alkynylaryl carbonyls, useful synthons for the accomplishment of many carbocyclic and heterocyclic motifs. Significantly, the strategy was extended to the one-pot synthesis of isobenzofurans via reduction followed by intramolecular 5-exo-dig cyclization.