Synthesis and Bioactivity of Novel N-Benzylic and N-Phenethylic Ephedrine Derivatives
Received: 28 June 2017
Accepted: 02 July 2017
23 August 2017 (eFirst)
A range of N-benzylic and N-phenethylic ephedrine derivatives were prepared in a one-pot procedure starting from the two enantiomers of ephedrine using the Potier reagent, and a polyfunctional aryl- or benzylic organozinc halide. The biological activity in indatraline MS Binding Assays addressing hDAT, hNET and hSERT was determined and discussed.