Synthesis of Cyanamides from Cyanogen Bromide under Mild Conditions through N-Cyanation of Allylic Tertiary AminesThe authors are grateful to the National Natural Science Foundation of China (Grant NO.21576026) and the Joint Fund of the National Natural Science Foundation of China and the China Academy of Engineering Physics (Grant NO.11176004) for financial support.
Received: 05 June 2017
Accepted after revision: 09 July 2017
17 August 2017 (eFirst)
Cyanamides were selectively formed through a one-step nucleophilic substitution reaction of allylic tertiary amines with cyanogen bromide. Because of the mild reaction conditions and good yields of the reaction, as well as the commercial availability of the starting materials, this new method represents a valuable tool for the synthesis of cyanamides through an N-deallylation reaction and an N-cyanation reaction in one pot.