Photoinduced Regioselective Lactonization of ortho-Iodobenzoic Acids with Alkenes: Synthesis of 3,4-Dihydroisocoumarin DerivativesWe are grateful for financial support from China NSFC (Nos. 21372055, 21472030 and 21672047) and SKLUWRE (No. 2017DX03).
Received: 12 June 2017
Accepted after revision: 18 July 2017
22 August 2017 (eFirst)
A photoinduced strategy for the synthesis of a variety of 3,4-dihydroisocoumarins has been realized. The reactions proceeded from ortho-iodobenzoic acids and alkenes through a photodehalogenative lactonization with NaHCO3 as the only additive in dimethyl sulfoxide (DMSO) to provide the desired products in moderate to good yields. This method offers a simple, mild, and environmentally friendly route to 3,4-dihydroisocoumarin derivatives.