DOI: 10.1055/s-0036-1588546
© Georg Thieme Verlag Stuttgart · New York

Tf2NH-Catalyzed 1,6-Conjugate Addition of Vinyl Azides with p-Quinone Methides: A Mild and Efficient Method for the Synthesis of β-Bis-Arylamides

Jayant Rathoda, b, Brijesh M. Sharmaa, b, Pramod S. Malic, Pradeep Kumar*a, b
  • aDivision of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune-411008, India   Email:
  • bAcademy of Scientific and Innovative Research (AcSIR), New Delhi-110025, India
  • cCentral NMR Facility, National Chemical Laboratory, Pune-411008, India
J. R and B. M. S thank the Council of Scientific and Industrial Research (CSIR), New Delhi for a Senior Research Fellowship. Dr. P. R. Rajamohanan [CSIR-NCL)] is thanked for NMR support, Ms. B. Santhakumari (CSIR-NCL) for the HRMS data; P. K also thanks the Council of Scientific and Industrial Research (CSIR), New Delhi for financial support as part of XII Five Year Plan under the title ORIGIN (CSC0108).
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Publication History

Received: 19 July 2017

Accepted after revision: 19 July 2017

Publication Date:
22 August 2017 (eFirst)


Tf2NH-catalyzed tandem 1,6-conjugate addition/Schmidt type rearrangement using vinyl azides and p-quinone methides to access a variety of β-bis-arylated amides is reported. The method is quick, efficient, mild, and high yielding with broad substrate scope.

Supporting Information