DOI: 10.1055/s-0036-1588549
© Georg Thieme Verlag Stuttgart · New York

Iodine-Catalyzed Regioselective Sulfenylation of 4H-Pyrido[1,2-a]pyrimidin-4-ones with Sulfonyl Hydrazides

Wenjie Liua, b, Shaohua Wang*a, b, Zhihao Caia, Ziying Lia, Jianwen Liua, Anda Wanga
  • aSchool of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou 510006, P. R. of China
  • bGuangdong Cosmetics Engineering & Technology Research Center, Guangzhou, 510006, P. R. of China   Email:
The work was financially supported by the Project for Enhanced Innovation of Guangdong Pharmaceutical University, Provincial Experimental Teaching Demonstration Center of Chemistry and Chemical Engineering.
Further Information

Publication History

Received: 16 June 2017

Accepted after revision: 18 July 2017

Publication Date:
22 August 2017 (eFirst)


A simple and efficient method for direct sulfenylation of 4H-pyrido[1,2-a]pyrimidin-4-ones with sulfonyl hydrazides has been developed. The transformation is catalyzed by iodine under metal-free conditions with high regioselectivity and good functional-group tolerance.

Supporting Information