Iodine-Catalyzed Regioselective Sulfenylation of 4H-Pyrido[1,2-a]pyrimidin-4-ones with Sulfonyl HydrazidesThe work was financially supported by the Project for Enhanced Innovation of Guangdong Pharmaceutical University, Provincial Experimental Teaching Demonstration Center of Chemistry and Chemical Engineering.
Received: 16 June 2017
Accepted after revision: 18 July 2017
22 August 2017 (eFirst)
A simple and efficient method for direct sulfenylation of 4H-pyrido[1,2-a]pyrimidin-4-ones with sulfonyl hydrazides has been developed. The transformation is catalyzed by iodine under metal-free conditions with high regioselectivity and good functional-group tolerance.