DOI: 10.1055/s-0036-1588561
© Georg Thieme Verlag Stuttgart · New York

Palladium-Catalyzed Cross-Coupling of 1,3,4-Oxadiazoles and Styrenes: An Efficient Method to Synthesize 2-Alkenyl-1,3,4- Oxadiazoles§

N. Salvanna*a, P. Raghavendar Reddyb, Biswanath Das*b
  • aOsmania University Postgraduate College, Narsapur, Medak, Telangana 502313, India
  • bNatural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India   Email:
Further Information

Publication History

Received: 23 June 2017

Accepted after revision: 31 July 2017

Publication Date:
25 August 2017 (eFirst)

§ Part 240 in the Series ‘Studies on Novel Synthetic Methodologies’


2-Alkenyl-1,3,4-oxadiazole derivatives have been prepared by cross-coupling of 1,3,4-oxadiazoles with styrenes by using palladium(II) trifluoroacetate [Pd(TFA)2] as a catalyst, 1,10-phenanthroline as a ligand, silver trifluoroacetate as an oxidant, and toluene as a solvent. The products were formed in high yields and no byproducts were detected.