DOI: 10.1055/s-0036-1588564
© Georg Thieme Verlag Stuttgart · New York

New Efficient Synthesis of 1,2,4-Trisubstituted Furans by a ­Sequential Passerini/Wittig/Isomerization Reaction Starting from Baylis–Hillman β-Bromo Aldehydes

Zhi-Lin Ren, Mei Sun, Zhi-Rong Guan, Ming-Wu Ding*
  • Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, P. R. of China   Email:
We gratefully acknowledge the financial support of this work by the National Natural Science Foundation of China (No. 21572075) and the 111 Project B17019.
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Publication History

Received: 12 June 2017

Accepted after revision: 26 July 2017

Publication Date:
25 August 2017 (eFirst)


A new and efficient synthesis of 1,2,4-trisubstituted furans from a Baylis–Hillman β-bromo aldehyde, an acid, an isocyanide, and methyl(diphenyl)phosphine, by a sequential Passerini condensation, Wittig reaction, and isomerization in the presence of triethylamine is reported.

Supporting Information