New Efficient Synthesis of 1,2,4-Trisubstituted Furans by a Sequential Passerini/Wittig/Isomerization Reaction Starting from Baylis–Hillman β-Bromo AldehydesWe gratefully acknowledge the financial support of this work by the National Natural Science Foundation of China (No. 21572075) and the 111 Project B17019.
Received: 12 June 2017
Accepted after revision: 26 July 2017
25 August 2017 (eFirst)
A new and efficient synthesis of 1,2,4-trisubstituted furans from a Baylis–Hillman β-bromo aldehyde, an acid, an isocyanide, and methyl(diphenyl)phosphine, by a sequential Passerini condensation, Wittig reaction, and isomerization in the presence of triethylamine is reported.