DOI: 10.1055/s-0036-1588565
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Benzamide Derivatives by the Reaction of Arenes and Isocyanides through a C–H Bond Activation Strategy

Mehdi Khalaj*a, Mahboubeh Taherkhanib, Seyed Mahmoud Mousavi-Safavia, Jafar Akbaria
  • aYoung Researchers and Elite Club, Buinzahra Branch, Islamic Azad University, Buinzahra, Iran
  • bYoung Researchers and Elite Club, Takestan Branch, Islamic Azad University, Takestan, Iran   Email:
Further Information

Publication History

Received: 10 July 2017

Accepted after revision: 19 August 2017

Publication Date:
15 September 2017 (eFirst)


A carbon–carbon bond formation reaction between isocyanides and benzene derivatives is reported. In contrast to traditional cross-coupling reactions, which require aryl halides or pseudohalides, we use a palladium catalyst to generate the aryl–palladium through C–H bond activation of arenes. This method offers an attractive approach to a range of benzamides from readily accessible benzene derivatives.