A Rh(III)-Catalyzed Cascade C–H Functionalization/C(sp3)–C(sp3) Formation/Cyclization Reaction for the Synthesis of Isoquinolinedione DerivativesFinancial support from the National Natural Science Foundation of China (No. 21372195) is gratefully acknowledged.
Received: 03 August 2017
Accepted after revision: 18 August 2017
25 September 2017 (eFirst)
A cascade C–H functionalization/C(sp3)–C(sp3) formation/cyclization reaction of N-methoxybenzamides with diazomalonates under rhodium(III) catalysis is developed for the efficient synthesis of isoquinolinedione derivatives. A plausible mechanism involving double migratory insertions of carbenes for the formation of C(sp2)–C(sp3) and C(sp3)–C(sp3) bonds by rhodium(III) catalysis is also proposed.