DOI: 10.1055/s-0036-1588566
© Georg Thieme Verlag Stuttgart · New York

A Rh(III)-Catalyzed Cascade C–H Functionalization/C(sp3)–C(sp3) Formation/Cyclization Reaction for the Synthesis of Isoquinolinedione Derivatives

Peng Baia, Kenneth L. Huangb, Zhi-Zhen Huang*a
  • aDepartment of Chemistry, Zhejiang University, Hangzhou 310028, P. R. of China   Email:
  • bLakeside High School, 533 Blue Ridge Drive, Augusta, GA 30809, USA
Financial support from the National Natural Science Foundation of China (No. 21372195) is gratefully acknowledged.
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Publication History

Received: 03 August 2017

Accepted after revision: 18 August 2017

Publication Date:
25 September 2017 (eFirst)


A cascade C–H functionalization/C(sp3)–C(sp3) formation/cyclization reaction of N-methoxybenzamides with diazomal­onates under rhodium(III) catalysis is developed for the efficient synthesis of isoquinolinedione derivatives. A plausible mechanism involving double migratory insertions of carbenes for the formation of C(sp2)–C(sp3) and C(sp3)–C(sp3) bonds by rhodium(III) catalysis is also proposed.

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