Studies Towards the Synthesis of (+)- and (–)-Anisomycin and Their Analogues
Received: 02 August 2017
Accepted after revision: 23 August 2017
04 October 2017 (eFirst)
Anisomycin shows potent biological activity and it has attracted much attention since its isolation in 1954, with around 13 total syntheses and 20 formal syntheses, and also two reports concerning analogues of anisomycin, reported to date. The present review highlights all of these synthetic approaches (around 35) to the total or formal synthesis of anisomycin along with its isomers and analogues.
2 Isolation and Therapeutic Importance
3 Total Synthesis of (+)-, (–)-, and (±)-Anisomycins and Their Analogues
4 Formal Synthesis of (+)- and (–)-Anisomycins and Their Analogues