DOI: 10.1055/s-0036-1588571
© Georg Thieme Verlag Stuttgart · New York

Preparation of Propargyl Amines in a ZnCl2–Dimethylurea Deep-Eutectic Solvent

Martin Obsta, Akriti Srivastavab, Sundarababu Baskaran*b, Burkhard König*a
We thank the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG 9209735) and DST (INT/FRG/DFG/P-44/2014) for financial support.
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Publication History

Received: 25 July 2017

Accepted after revision: 29 August 2017

Publication Date:
21 September 2017 (eFirst)


The coupling of an aldehyde, an amine, and an alkyne to yield propargyl amines was performed in a deep-eutectic solvent composed of zinc chloride and dimethylurea. The deep-eutectic solvent acts simultaneously as catalyst and solvent giving access to a variety of propargyl amines, which were isolated in moderate to very good yields.

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