Preparation of Propargyl Amines in a ZnCl2–Dimethylurea Deep-Eutectic SolventWe thank the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG 9209735) and DST (INT/FRG/DFG/P-44/2014) for financial support.
Received: 25 July 2017
Accepted after revision: 29 August 2017
21 September 2017 (eFirst)
The coupling of an aldehyde, an amine, and an alkyne to yield propargyl amines was performed in a deep-eutectic solvent composed of zinc chloride and dimethylurea. The deep-eutectic solvent acts simultaneously as catalyst and solvent giving access to a variety of propargyl amines, which were isolated in moderate to very good yields.