Palladium-Catalyzed Decarboxylation of Benzyl FluorobenzoatesThis work was supported by Grant-in-Aid for Young Scientists (B) (JSPS KAKENHI Grant Number JP17K14450).
Received: 19 June 2017
Accepted after revision: 28 August 2017
26 September 2017 (eFirst)
Published as part of the Cluster CO Activation
The decarboxylation of benzyl fluorobenzoates has been developed by using the palladium catalyst prepared in situ from Pd(η3-allyl)Cp and bulky monophosphine ligand XPhos. The catalytic reaction afforded a range of fluorinated diarylmethanes in good yields with broad functional-group compatibility. The substrates were readily synthesized by condensation of the corresponding benzoic acid with benzyl alcohol. Therefore, the transformation is formally regarded as a cross-coupling reaction between fluorine-containing benzoic acids and benzyl alcohols.