Tuning the Properties of Penetrating Peptides by Oxime Conjugation

Abstract

We here describe the application of oxime bond formation between a peptide scaffold and different aldehydes to modify the transporting capabilities of penetrating peptides. We show that bonds such as oximes offer a great synthetic advantage for the modification of the properties of model penetrating peptides. We believe that this approach will allow the development of improved intracellular delivery vehicles.

Key words

peptide chemistry - penetrating peptides - supramolecular chemistry - membrane transport - solid-phase peptide synthesis

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