Iridium-Catalyzed Site-Selective C–H Borylation of 2-Pyridones
Received: 24 January 2017
Accepted after revision: 07 February 2017
02 March 2017 (eFirst)
An iridium-catalyzed site-selective C–H borylation of 2-pyridones has been developed. The site selectivity is predominantly controlled by steric factors, and we can access C4, C5, and C6 C–H on the 2-pyridone ring by the judicious choice of ligand and solvent. Subsequent Suzuki–Miyaura cross-coupling of the borylated products also proceeds to form the corresponding arylated pyridones in good overall yields.