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Synthesis 2017; 49(09): 1955-1968
DOI: 10.1055/s-0036-1588748
DOI: 10.1055/s-0036-1588748
feature
Metal-Free Synthesis of Oxazinones and Their Reductive Ring Opening to Provide Cyclopropyl Carbinols
Further Information
Publication History
Received: 03 February 2017
Accepted after revision: 23 February 2017
Publication Date:
14 March 2017 (online)
Abstract
General routes for the synthesis of 1,3-oxazin-4-ones are discussed, with particular attention paid to recent developments in the field. The syntheses of amine functionalised cyclopropyl carbinols via a hydride-mediated reduction of various 5-chloroethyl-1,3-oxazin-4-enones in moderate to good yield are disclosed. This new method provides an opportunity to access greater structural diversity within these useful synthetic building blocks.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588748.
- Supporting Information
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