A Mild and Efficient Method for the Syntheses and Regioselective Ring-Opening of Aziridines

Abstract

We have developed a new synthetic method for the synthesis of aziridines using Chloramine-T as an effective reagent in the presence of NH₂OH·HCl and NaIO₄. We found that the same combination of NH₂OH·HCl and NaIO₄ is also very effective for nucleophilic ring opening of aziridines.

Key words

aziridines - difunctionalization - aminoiodide - in situ generated iodine - room temperature

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