Palladium-Catalyzed Direct C2-Arylation of Benzo[b]thiophenes with Electron-Rich Aryl Halides: Facile Access to Thienoacene DerivativesSupported by: This work was partly supported by a grant to M.M. from the JSPS KAKENHI (Grant-in Aid for Scientific Research (S)) (JP 24225002)
Received: 22 February 2017
Accepted after revision: 16 March 2017
11 April 2017 (eFirst)
Dedicated to Professor Victor Snieckus on the occasion of his 80th birthday
Direct coupling reaction of benzo[b]thiophene and electron-rich aryl bromides was achieved under Pd2(dba)3/SPhos catalysis in the presence of NaOt-Bu. The reaction system was applied for the installation of 2-(methylthio)phenyl group onto thiophene-fused polyaromatic molecules, demonstrating facile synthesis of precursors for thienoacene derivatives.