Synthesis 2017; 49(17): 3931-3936
DOI: 10.1055/s-0036-1589010
special topic
© Georg Thieme Verlag Stuttgart · New York

Cobalt-Catalyzed Monoselective ortho-C–H Ethylation of Carboxamides with Triethylaluminum

Kun Xu  *
College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, Henan, 473061, P. R. of China   eMail: [email protected]   eMail: [email protected]
,
Zhoumei Tan
College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, Henan, 473061, P. R. of China   eMail: [email protected]   eMail: [email protected]
,
Haonan Zhang
College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, Henan, 473061, P. R. of China   eMail: [email protected]   eMail: [email protected]
,
Sheng Zhang*
College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, Henan, 473061, P. R. of China   eMail: [email protected]   eMail: [email protected]
› Institutsangaben
We are grateful to the Natural Science Foundation of China (21602119, U1504208), and for financial support from He’nan Provincial Department of Science and Technology (152300410117).
Weitere Informationen

Publikationsverlauf

Received: 15. Februar 2017

Accepted after revision: 30. März 2017

Publikationsdatum:
29. Mai 2017 (online)


Published as part of the Special Topic Cobalt in Organic Synthesis

Abstract

A 1,10-phenanthroline ligated cobalt catalyst is reported for the ortho-C–H ethylation of aromatic, heteroaromatic, and alkenyl carboxamides with inexpensive triethylaluminum. This reaction represented the first example of cobalt-catalyzed monoselective direct ortho-C–H ethylation reaction with aluminum reagent as an alkyl donor.

Supporting Information

 
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