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Synthesis 2017; 49(17): 3968-3974
DOI: 10.1055/s-0036-1589041
DOI: 10.1055/s-0036-1589041
paper
Oxidative Cleavage of Enamides with Hypervalent Iodine(III)/TMSN3 under an Air Atmosphere
We gratefully acknowledge the National Science Foundation of China (21602213, 21522208, 21372209) for financial support.Further Information
Publication History
Received: 29 March 2017
Accepted after revision: 05 May 2017
Publication Date:
20 June 2017 (online)
Abstract
An oxidative cleavage of C–C double bonds of enamides promoted by hypervalent iodine(III)/TMSN3 under an air atmosphere is developed. This reaction provides a new approach to construct various cyanobenzamides, which offers further synthetic potential for the preparation of industrial and pharmaceutical nitrogen- and oxygen-containing molecules, and exhibits good functional group tolerance, broad substrate scope and mild conditions.
Supporting Information
- Supporting information for this article is available online at https://doi.org /10.1055/s-0036-1589041.
- Supporting Information
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