Thieme Chemistry Journals Awardees – Where Are They Now?
Titanium-Catalyzed Hydroaminoalkylation of Vinylsilanes and a One-Pot Procedure for the Synthesis of 1,4-Benzoazasilines
Received: 29 March 2017
Accepted after revision: 10 May 2017
18 July 2017 (eFirst)
Vinylsilanes undergo intermolecular alkene hydroaminoalkylation with secondary amines in the presence of a titanium mono(aminopyridinato) catalyst to give the branched hydroaminoalkylation products with high regioselectivity. Corresponding reactions of a suitable (2-bromophenyl)vinylsilane combined with a subsequent intramolecular Buchwald–Hartwig amination result in the development of an elegant one-pot procedure for the synthesis of 1,4-benzoazasilines.