DOI: 10.1055/s-0036-1589048
© Georg Thieme Verlag Stuttgart · New York

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Titanium-Catalyzed Hydroaminoalkylation of Vinylsilanes and a One-Pot Procedure for the Synthesis of 1,4-Benzoazasilines

Lars H. Lühning, Michael Rosien, Sven Doye*
  • Institut für Chemie, Universität Oldenburg, Carl-von-Ossietzky-Straße 9–11, 26111 Oldenburg, Germany   Email:
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Publication History

Received: 29 March 2017

Accepted after revision: 10 May 2017

Publication Date:
18 July 2017 (eFirst)


Vinylsilanes undergo intermolecular alkene hydroaminoalkylation with secondary amines in the presence of a titanium mono(aminopyridinato) catalyst to give the branched hydroaminoalkylation products with high regioselectivity. Corresponding reactions of a suitable (2-bromophenyl)vinylsilane combined with a subsequent intramolecular Buchwald–Hartwig amination result in the development of an elegant one-pot procedure for the synthesis of 1,4-benzoazasilines.

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