Synthesis 2017; 49(17): 4045-4054
DOI: 10.1055/s-0036-1589050
paper
© Georg Thieme Verlag Stuttgart · New York

Facile Access to Amido (Thio)xanthates under Eco-Friendly Conditions by One-Pot Three-Component Reaction (3-CR)

Max Franz
Institute of Chemistry, University of Oldenburg, Carl-von-Ossietzky-Str. 9–11, 26129 Oldenburg, Germany   Email: [email protected]
,
Timo Stalling
Institute of Chemistry, University of Oldenburg, Carl-von-Ossietzky-Str. 9–11, 26129 Oldenburg, Germany   Email: [email protected]
,
Raoul Schaper
Institute of Chemistry, University of Oldenburg, Carl-von-Ossietzky-Str. 9–11, 26129 Oldenburg, Germany   Email: [email protected]
,
Marc Schmidtmann
Institute of Chemistry, University of Oldenburg, Carl-von-Ossietzky-Str. 9–11, 26129 Oldenburg, Germany   Email: [email protected]
,
Jürgen Martens*
Institute of Chemistry, University of Oldenburg, Carl-von-Ossietzky-Str. 9–11, 26129 Oldenburg, Germany   Email: [email protected]
› Author Affiliations
Further Information

Publication History

Received: 06 April 2017

Accepted after revision: 15 May 2017

Publication Date:
25 July 2017 (online)


Abstract

A straightforward three-component reaction (3-CR) for the preparation of a variety of biologically interesting amido (thio)xanthates has been developed. By the proper choice of a potassium (thio)xanthate salt, a cyclic or acyclic imine, and an acyl chloride as substrates a broad scope with respect to the substituents can be realized. This operationally simple one-pot method proceeds under mild and environmentally friendly conditions while potassium chloride is produced as the single waste-product.

Supporting Information

 
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