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Synthesis 2017; 49(18): 4229-4246
DOI: 10.1055/s-0036-1589054
DOI: 10.1055/s-0036-1589054
special topic
Lewis Acid Mediated Cyclizations: Diastereoselective Synthesis of Six- to Eight-Membered Substituted Cyclic Ethers
The National Institutes of Health.Weitere Informationen
Publikationsverlauf
Received: 19. April 2017
Accepted after revision: 22. Mai 2017
Publikationsdatum:
25. Juli 2017 (online)
Published as part of the Special Topic Modern Cyclization Strategies in Synthesis
Abstract
Cyclic ethers are widely abundant in natural products. Cyclic ether templates are also utilized in drug design and medicinal chemistry. Although the synthetic processes for this class of compounds have been studied extensively with respect to five- and six-membered rings, medium-sized cyclic ethers are synthetically more challenging due to a variety of factors. Herein, we report our results on the Lewis acid catalyzed synthesis of medium-sized cyclic ethers in a diastereoselective manner.
Key words
cyclization - cyclic ethers - diastereoselectivity - Lewis acids - oxacycles - oxepanes - oxocenes - polycyclesSupporting Information
- Supporting information for this article is available online at https://doi.org /10.1055/s-0036-1589054.
- Supporting Information
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