Synlett 2017; 28(17): 2291-2294
DOI: 10.1055/s-0036-1589065
© Georg Thieme Verlag Stuttgart · New York

One-Pot Synthesis of Unsymmetrical Bis(4-Hydroxycoumarin-3-yl)methanes

Sinki Kolitaa, Leema Duttaa, Pankaj Dasb, Pulak J Bhuyan*a
  • aApplied Organic Chemistry Group, CSIR-North East Institute of Science and Technology, Jorhat 785006, Assam, India
  • bDepartment of Chemistry, Dibrugarh University, Dibrugarh-786004, Assam, India   Email:
Further Information

Publication History

Received: 25 April 2017

Accepted after revision: 02 June 2017

Publication Date:
13 July 2017 (eFirst)


Unsymmetrical bis(4-hydroxycoumarin-3-yl)methane derivatives have been synthesized from 4-hydroxycoumarins, aldehydes, and secondary amines via 3-(aminoalkyl)-4-hydroxycoumarin intermediates, followed by substitution.

Supporting Information