A Practical Gram-Scale Synthesis of Acrylohydroxamic AcidThis work was supported by a contract from ALKYMOS, Inc. Funding for the ApexII diffractometer was provided by the National Science Foundation (MRI, CHE-0420497).
Received: 15 July 2017
Accepted after revision: 09 August 2017
30 August 2017 (eFirst)
Acrylohydroxamic acid, which is a useful monomer for the preparation of polymeric materials, has been prepared in a straightforward, two-step synthesis from readily available starting materials. The key steps are coupling of acrylic acid with O-tetrahydropyranylhydroxyl amine to provide protection of the hydroxylamine functionality, followed by acid cleavage of the protecting group.