An Efficient Fe/H2O Medium in situ Reduction and Cyclization Reaction for the Synthesis of Pyrazolo[3,4-a]acridin-10-one and Pyrazolo[4,3-a]acridin-10-one Derivatives

Hui Xu; Lei Li; Cong Lin; Wang Kou; Zhi Ling; Zhongyun Xu; Liangce Rong

doi:10.1055/s-0036-1589124

Synthesis, Table of Contents

Synthesis 2018; 50(03): 583-592
DOI: 10.1055/s-0036-1589124

paper

An Efficient Fe/H₂O Medium in situ Reduction and Cyclization Reaction for the Synthesis of Pyrazolo[3,4-a]acridin-10-one and Pyrazolo[4,3-a]acridin-10-one Derivatives

Authors

Hui Xu

School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu, P. R. of China Email: lcrong@jsnu.edu.cn
Lei Li

School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu, P. R. of China Email: lcrong@jsnu.edu.cn
Cong Lin

School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu, P. R. of China Email: lcrong@jsnu.edu.cn
Wang Kou

School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu, P. R. of China Email: lcrong@jsnu.edu.cn
Zhi Ling

School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu, P. R. of China Email: lcrong@jsnu.edu.cn
Zhongyun Xu

School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu, P. R. of China Email: lcrong@jsnu.edu.cn
Liangce Rong *

School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu, P. R. of China Email: lcrong@jsnu.edu.cn

Abstract

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Abstract

An efficient and simple method for the synthesis of pyrazolo[3,4-a]acridine and pyrazolo[4,3-a]acridine derivatives directly form nitro compounds by in situ reduction and cyclization reaction under Fe/H₂O medium is reported. Compared to amino compounds, nitro compounds are more stable and easier to obtain. In addition, because iron is a nontoxic, inexpensive, and environmentally friendly reductant, this method is especially suitable for organic synthesis. The other advantages of this process are cheap raw materials, less pollution, and wide substrate range.

Key words

in situ reductions - nitro compounds - iron - pyrazolo-[3,4-a]-acridin-10-one - pyrazolo[4,3-a]acridin-10-one

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References

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Supplementary Material

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