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Synthesis 2018; 50(11): 2131-2149
DOI: 10.1055/s-0036-1589533
DOI: 10.1055/s-0036-1589533
review
Recent Developments in the Synthesis of Pyrido[1,2-a]benzimidazoles
Further Information
Publication History
Received: 03 January 2018
Accepted after revision: 21 February 2018
Publication Date:
24 April 2018 (online)
◊ These authors contributed equally to this work.
Abstract
Pyrido[1,2-a]benzimidazole is one of the most important azaheterocyclic compounds consisting of three fused aromatic rings. Molecules containing this core have displayed a wide range of applications in the field of medicinal chemistry. The synthesis of pyrido[1,2-a]benzimidazole and its derivatives has attracted organic chemists because of its tremendous utility in interdisciplinary branches of chemistry. In this context, this review discusses the main advances in the synthesis of pyrido[1,2-a]benzimidazoles via metal-mediated and metal-free reactions from 2000 to 2016.
1 Introduction
2 Synthetic Approaches to Pyrido[1,2-a]benzimidazoles
2.1 Type I: Transition-Metal-Catalyzed Methods
2.2 Type II: Metal-Free Approaches
3 Conclusion
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