Synthesis 2018; 50(11): 2131-2149
DOI: 10.1055/s-0036-1589533
review
© Georg Thieme Verlag Stuttgart · New York

Recent Developments in the Synthesis of Pyrido[1,2-a]benzimidazoles

Rajni Khajuria
a  Department of Chemistry, University of Jammu, Jammu 180006, India   Email: [email protected]
b  Department of Chemistry and Chemical Sciences, Central University of Jammu, Jammu 181143, India
,
Sk. Rasheed
c  Academy of Scientific and Innovative Research (AcSIR), New Delhi 110001, India   Email: [email protected]
d  Medicinal Chemistry Division, Indian Institute of Integrative Medicine (CSIR), Jammu 180001, India
,
Chhavi Khajuria
e  Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India
,
Kamal K. Kapoor*
a  Department of Chemistry, University of Jammu, Jammu 180006, India   Email: [email protected]
,
Parthasarathi Das*
c  Academy of Scientific and Innovative Research (AcSIR), New Delhi 110001, India   Email: [email protected]
d  Medicinal Chemistry Division, Indian Institute of Integrative Medicine (CSIR), Jammu 180001, India
f  Department of Applied Chemistry, Indian Institute of Technology (Indian School of Mines), Dhanbad 826004, India
› Author Affiliations
Further Information

Publication History

Received: 03 January 2018

Accepted after revision: 21 February 2018

Publication Date:
24 April 2018 (online)


These authors contributed equally to this work.

Abstract

Pyrido[1,2-a]benzimidazole is one of the most important azaheterocyclic compounds consisting of three fused aromatic rings. Molecules containing this core have displayed a wide range of applications in the field of medicinal chemistry. The synthesis of pyrido[1,2-a]benzimidazole and its derivatives has attracted organic chemists because of its tremendous utility in interdisciplinary branches of chemistry. In this context, this review discusses the main advances in the synthesis of pyrido[1,2-a]benzimidazoles via metal-mediated and metal-free reactions from 2000 to 2016.

1 Introduction

2 Synthetic Approaches to Pyrido[1,2-a]benzimidazoles

2.1 Type I: Transition-Metal-Catalyzed Methods

2.2 Type II: Metal-Free Approaches

3 Conclusion

 
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