An Efficient Protocol for the Synthesis of O-Fluoroalkylisoureas through Copper-Catalysed, Three-Component Reaction of Cyanamides, Fluoroalcohols and Diaryliodonium TriflatesThe authors acknowledge the Natural Science Foundation of Hainan Province (grant numbers 20162015, 20152027), the National Natural Science Foundation of China (51263006) and Hainan Province International Science and Technology Specific (KJHZ2014-02) for financial support of this work
Received: 15 May 2017
Accepted after revision: 20 June 2017
08 August 2017 (online)
A copper-catalysed, three-component reaction involving cyanamides, fluoroalcohols and diaryliodonium triflates is disclosed for the synthesis of O-fluoroalkylisoureas. Various O-fluoroalkylisoureas were obtained in good yields by using simple and readily available substrates. Moreover, C–H activation of O-fluoroalkylisoureas mediated by PhI(OAc)2 was established to obtain 2-fluoroalkoxybenzimidazoles in high yields at room temperature.