CC BY ND NC 4.0 · SynOpen 2017; 01(01): 0076-0083
DOI: 10.1055/s-0036-1590828
paper
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An Efficient Protocol for the Synthesis of O-Fluoroalkylisoureas through Copper-Catalysed, Three-Component Reaction of Cyan­amides, Fluoroalcohols and Diaryliodonium Triflates

Jihui Lia, b, Weiguang Yua, b, Yifeng Houa, b, Wenxing Fua, b, Shuying Xu*a, b, Yucang Zhang*a, b
  • aKey Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources in Hainan University, Haikou 570228, P. R. of China
  • bCollege of Materials and Chemical Engineering, Hainan University, Haikou 570228, P. R. of China   Email: xushuying1980@hainu.edu.cn   Email: yczhang@hainu.edu.cn
The authors acknowledge the Natural Science Foundation of Hainan Province (grant numbers 20162015, 20152027), the National Natural Science Foundation of China (51263006) and Hainan Province International Science and Technology Specific (KJHZ2014-02) for financial support of this work
Further Information

Publication History

Received: 15 May 2017

Accepted after revision: 20 June 2017

Publication Date:
08 August 2017 (online)

Abstract

A copper-catalysed, three-component reaction involving cyan­amides, fluoroalcohols and diaryliodonium triflates is disclosed for the synthesis of O-fluoroalkylisoureas. Various O-fluoroalkylisoureas were obtained in good yields by using simple and readily available substrates. Moreover, C–H activation of O-fluoroalkylisoureas mediated by PhI(OAc)2 was established to obtain 2-fluoroalkoxybenzimidazoles in high yields at room temperature.

Supporting Information

 
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