DOI: 10.1055/s-0036-1590856
© Georg Thieme Verlag Stuttgart · New York

Nef–Perkow–Mumm Cascade towards Imido Phosphate Derivatives

Aurélie Dos Santosa, Marie Cordierb, Laurent El Kaïm*a
  • aLaboratoire de Synthèse Organique, CNRS, Ecole Polytechnique, ENSTA ParisTech – UMR 7652, Université Paris-Saclay, 828 Bd des Maréchaux, 91128 Palaiseau, France   Email:   Email:
  • bLaboratoire de Chimie Moléculaire, CNRS, Ecole Polytechnique – UMR 9168, Université Paris-Saclay, Route de Saclay, 91128 Palaiseau, France
Further Information

Publication History

Received: 17 May 2017

Accepted after revision: 06 July 2017

Publication Date:
11 August 2017 (eFirst)


A one-pot, four-component synthesis of imido phosphates has been achieved using a Nef–Perkow sequence followed by addition of carboxylic acid derivatives. The final imido moiety is formed via a Mumm rearrangement of an intermediate imidate.

Supporting Information