A Solvent-Free Reaction for Silyl Enol Ethers SynthesisThe authors gratefully thank the Fondazione Cassa di Risparmio di Perugia (Grant no. FCR 2015.0381.021) for supporting the research.
Received: 22 May 2017
Accepted after revision: 20 July 2017
22 August 2017 (eFirst)
Silyl enol ethers are extremely useful nucleophilic intermediates for chemical transformations because they are synthetically versatile substrates for a wide range of C–C bond-forming reactions. Here, we present a new, mild, and solvent-free procedure for the synthesis of silyl enol ethers that employs a catalytic amount of solid-supported base and an equimolar amount of N,O-(bistrimethylsilyl)acetamide as a silylating agent.