Synlett
DOI: 10.1055/s-0036-1590876
letter
© Georg Thieme Verlag Stuttgart · New York

A Solvent-Free Reaction for Silyl Enol Ethers Synthesis

Chiara Morozzi, Ornelio Rosati, Massimo Curini, Daniela Lanari*
  • Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, via del Liceo, 1, 06123 Perugia, Italy   Email: daniela.lanari@unipg.it
The authors gratefully thank the Fondazione Cassa di Risparmio di Perugia (Grant no. FCR 2015.0381.021) for supporting the research.
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Publication History

Received: 22 May 2017

Accepted after revision: 20 July 2017

Publication Date:
22 August 2017 (eFirst)

Abstract

Silyl enol ethers are extremely useful nucleophilic intermediates for chemical transformations because they are synthetically versatile substrates for a wide range of C–C bond-forming reactions. Here, we present a new, mild, and solvent-free procedure for the synthesis of silyl enol ethers that employs a catalytic amount of solid-supported base and an equimolar amount of N,O-(bistrimethylsilyl)acetamide as a silylating agent.

Supporting Information