Synthesis 2017; 49(23): 5211-5216
DOI: 10.1055/s-0036-1590879
paper
© Georg Thieme Verlag Stuttgart · New York

Copper-Catalyzed C–S Cross-Coupling Reaction: S-Arylation of Arylthioureas

Hui Zhu
School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, P. R. of China
,
Xing Liu
School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, P. R. of China
,
Cai-Zhu Chang
School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, P. R. of China
,
Zhi-Bing Dong*
School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, P. R. of China
Key Laboratory of Green Chemical Process, Ministry of Education, Wuhan Institute of Technology, Wuhan 430205, P. R. of China   Email: dzb04982@wit.edu.cn
› Author Affiliations
We thank the National Natural Science Foundation of China (21302150), Hubei Provincial Department of Education (D20131501), Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry [2012]1707, foundation of Chutian distinguished fellow from Hubei Provincial Department of Education, foundation of High-end Talent Cultivation Program from Wuhan Institute of Technology.
Further Information

Publication History

Received: 22 June 2017

Accepted after revision: 19 July 2017

Publication Date:
22 August 2017 (eFirst)

Abstract

A simple and efficient copper-catalyzed S-arylation of aryl­thioureas was developed. Arylthioureas were smoothly converted into aryl-isothioureas with good yield by copper-catalyzed S-arylation. The features of this method include the use of a ligand-free catalyst, good yield, short reaction time, and broad substrate scope. The method provides a facile and convenient preparation of some potentially biologically active compounds.

Supporting Information

 
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