Synthesis 2017; 49(23): 5211-5216
DOI: 10.1055/s-0036-1590879
paper
© Georg Thieme Verlag Stuttgart · New York

Copper-Catalyzed C–S Cross-Coupling Reaction: S-Arylation of Arylthioureas

Hui Zhua, Xing Liua, Cai-Zhu Changa, Zhi-Bing Dong*a, b
  • aSchool of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, P. R. of China
  • bKey Laboratory of Green Chemical Process, Ministry of Education, Wuhan Institute of Technology, Wuhan 430205, P. R. of China   Email: dzb04982@wit.edu.cn
We thank the National Natural Science Foundation of China (21302150), Hubei Provincial Department of Education (D20131501), Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry [2012]1707, foundation of Chutian distinguished fellow from Hubei Provincial Department of Education, foundation of High-end Talent Cultivation Program from Wuhan Institute of Technology.
Further Information

Publication History

Received: 22 June 2017

Accepted after revision: 19 July 2017

Publication Date:
22 August 2017 (eFirst)

Abstract

A simple and efficient copper-catalyzed S-arylation of aryl­thioureas was developed. Arylthioureas were smoothly converted into aryl-isothioureas with good yield by copper-catalyzed S-arylation. The features of this method include the use of a ligand-free catalyst, good yield, short reaction time, and broad substrate scope. The method provides a facile and convenient preparation of some potentially biologically active compounds.

Supporting Information

 
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