Synthesis
DOI: 10.1055/s-0036-1590881
short review
© Georg Thieme Verlag Stuttgart · New York

Recent Developments in the Deoxyfluorination of Alcohols and Phenols: New Reagents, Mechanistic Insights, and Applications

Wen-Li Hua, Xiang-Guo Hu*a, Luke Hunter*b
  • aNational Engineering Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022, P. R. of China   Email: huxiangg@iccas.ac.cn
  • bSchool of Chemistry, UNSW, Sydney, NSW 2052, Australia   Email: l.hunter@unsw.edu.au
XGH thanks the Natural Science Foundation of China (21502076), Natural Science Foundation of Jiangxi Province (20161BAB213068) and Outstanding Young Talents Scheme of Jiangxi Province (2017) for support.
Further Information

Publication History

Received: 13 June 2017

Accepted after revision: 18 July 2017

Publication Date:
28 August 2017 (eFirst)

Abstract

This short review describes the development of new reagents and methods for the deoxyfluorination of phenols and alcohols during the period of 2011 to 2017. Important advances in the mechanistic understanding of these processes are discussed. The continuing importance of deoxyfluorination chemistry for the synthesis of valuable target molecules is highlighted through case studies including examples of 18F-radiosynthesis and the preparation of exotic multifluorinated compounds.

1 Introduction

2 New Deoxyfluorination Reagents

3 Novel Applications of ‘Legacy’ Deoxyfluorinating Reagents

4 Conclusions and Future Directions