DOI: 10.1055/s-0036-1590886
© Georg Thieme Verlag Stuttgart · New York

Recyclable [Ce(l-Pro)2]2 (Oxa) used as Heterogeneous Catalyst: One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones in Ethanol

Ramesh Katla*, Rakhi Chowrasia, Caren D. G. da Silva, Aline R. de Oliveira, Beatriz F. dos Santos, Nelson L. C. Domingues*
  • Organic Catalysis and Biocatalysis Laboratory OCBL/ FACET, Federal University of Grande Dourados—UFGD, Dourados/Itahúm rod. km 12 s/n, Zip Code 79804-970, Dourados, MS, Brazil   Email:   Email:
Brazilian authors (R. K. and N. L. C. D) thank Conselho Nacional de Desenvolvimento Científico e Tecnológico for BJT fellowships and for financial support (Processos: 314140/2014-0 and 400706/2014-8 CNPq - Brazil) and Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT-PRONEM­-Brazil). One of the Brazilian authors also thanks Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES - Brazil) for her fellowship.
Further Information

Publication History

Received: 06 June 2017

Accepted after revision: 27 July 2017

Publication Date:
24 August 2017 (eFirst)


[Ce(l-Pro)2]2 (Oxa) was used as a recyclable heterogeneous catalyst under mild conditions for the preparation of 2-aryl-2,3-dihydroquinazolin-4(1H)-one derivatives. The one-pot protocol proceeds in ethanol using anthranilamide with several aldehydes at 50–55 °C. The catalyst can be recycled and reused three cycles without significant loss of catalytic activity.

Supporting Information