Copper-Catalyzed C–N Bond Exchange of N-Heterocyclic Substituents around Pyridine and Pyrimidine CoresThe authors thank the National Natural Science Foundation of China for financial support (grant number 21466033), the Program for Changjiang Scholars and Innovative Research Team in University (Grant No. IRT_15R46), and Yangtze River scholar research project of Shihezi University (Grant No. CJXZ201601).
Received: 02 May 2017
Accepted after revision: 03 August 2017
28 August 2017 (eFirst)
S. Tao and E. Ji contributed equally.
A copper-catalyzed transfer N-heteroarylation strategy using a C–N bond exchange reaction is described. This reaction accommodates a wide range of pyridine and pyrimidine rings bearing halogen atoms, which have wide utility for subsequent transformations. This method provides a direct and operationally simple approach for modifying complex molecules by the exchange of N-heterocyclic substituents.