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Synthesis 2017; 49(23): 5120-5130
DOI: 10.1055/s-0036-1590893
DOI: 10.1055/s-0036-1590893
paper
Copper-Catalyzed C–N Bond Exchange of N-Heterocyclic Substituents around Pyridine and Pyrimidine Cores
The authors thank the National Natural Science Foundation of China for financial support (grant number 21466033), the Program for Changjiang Scholars and Innovative Research Team in University (Grant No. IRT_15R46), and Yangtze River scholar research project of Shihezi University (Grant No. CJXZ201601).Further Information
Publication History
Received: 02 May 2017
Accepted after revision: 03 August 2017
Publication Date:
28 August 2017 (online)
S. Tao and E. Ji contributed equally.
Abstract
A copper-catalyzed transfer N-heteroarylation strategy using a C–N bond exchange reaction is described. This reaction accommodates a wide range of pyridine and pyrimidine rings bearing halogen atoms, which have wide utility for subsequent transformations. This method provides a direct and operationally simple approach for modifying complex molecules by the exchange of N-heterocyclic substituents.
Key words
copper - pyridines - N-heterocyclic compounds - C–N bond exchange - transfer functionalizationSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1590893.
- Supporting Information
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