N1-Arylation of 1,4-Benzodiazepine-2-ones with Diaryliodonium SaltsR.K. is funded by an EPSRC/AZ funded PhD studentship (EP/M507568/1) with additional support from AstraZeneca [14550001 (SME)] and Tocris Biosciences. The EPSRC is also thanked for funding the UK National Crystallography Service
Received: 13 July 2017
Accepted after revision: 06 September 2017
25 September 2017 (eFirst)
A library of N1-arylated 5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-ones has been synthesized starting with unsymmetrical diaryliodonium salts using aqueous ammonia as a base. This can also be applied to a similar 1,3,4-benzotriazepin-2-one derivative.